As time passed and the smoke cleared, many Americans forgot the sense of anger and grief that was pervasive in the aftermath of 9/11. Some dismissed the victories achieved in dismantling of al Qaeda cells around the globe as insignificant or somehow inevitable. And our elected officials forswore our efforts to capture, hold and interrogate […]

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To investigate these questions, we used molecular docking to screen >500 000 fragments against homology models of the A3 and A1 adenosine receptors (ARs) with the goal to discover A3AR selective ligands. Twenty one fragments with predicted A3AR specific binding were evaluated in live cell fluorescence based assays; of eight verified ligands, six displayed A3/A1 […]

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A revised differential enhances the precision of power transfer, while the PDK dual clutch transmission (the only gearbox available) gains a centrifugal pendulum for smoothness. The dynamic engine mounts now work harder for crisper response, and the variable damping rates have been extended at both ends for a wider range of settings. If you’re a […]

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